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In controlled clinical trials of patients with cancer, darbepoetin alfa and other ESAs increased the risks for death and serious adverse cardiovascular reactions.

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Patients were excluded if they were less than 18 years of age as of June 1, 2009; had unknown gender; or had a history of Darbepoetin alfa or Epoetin alfa subcutaneous (s.

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Of the 1801 patients with CKD in clinical studies of darbepoetin alfa, 44% were age 65 and over, while 17% were age 75 and over.

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Damage to the skin changes skin flora, resulting in more frequent colonization by staphylococci and gram-negative bacteria.

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