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Gleevec is a really wonderful medication that saves lives and helps people maintain clear mind. I'v been on it for more than seven years now and I've had no side effects with it. You just have to be careful when taking the medication together with other strong drugs. For example I had to stop taking Interferon in order to get my heart function back to normal. But that's not a problem anymore as Gleevec offers so many more benefits. First of all I am still alive due to this medication. And I have been in remission for seven years, isn't it an evidence of the highest quality of the drug! I know that many people complain of nasty side effects and it's natural as we are all individuals and there can be no single solution equally good for all of us. So for some people Gleevec is the best solution, others have to continue their search. But when it comes to cancer, the most important thing is not to hang your head and continue searching. Cause there is a solution, you just have to find it. God bless us all!

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And then on Entresto you talked about prior authorization, is any of that entail a fail first policy where patients have to fail either an ACE or an ARB before they get clearance to go on Entresto?

Gleevec and two second-generation CML drugs that came after it are success stories in targeted therapy.

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The exclusion criteria were as follows: 1 with severe complications of hypertension such as hypertensive heart disease, stroke or renal failure and 2 could not be followed for 12 months.

Most clinical trials are designed to test a new treatment against a standard treatment to find out whether the new treatment has any added benefit.

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Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation".

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Imatinib (Gleevec in the USA and Glilvec elsewhere) is a relatively non-toxic, well-tolerated, targeted therapy for GIST cancer.

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Does anyone know whether or not Gleevec might work even if Dasatinib didn't?

As coincidence would have it, in the very year that Nixon launched the war on cancer, an unknown biologist named Judah Folkman published a paper proposing that metastatic cells survive, and become deadly, only if they grow blood vessels to keep themselves supplied with nutrients.

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