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I had a total hysterectomy when I was 28. I started on Premarin for a few years and then changed to the Vivelle patch for the last 8 years with no side effects. But I was also on the lower doses 0.25 and just recently went up to 0.75.
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The original manufacturer uses a brand name whereas a generic drug is usually called by the name of the active ingredient.
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Estradiol Patch (estradiol): I have been on the patch since my hysterectomy four years ago. I have gradually decreased the dosage and have tried to get off it totally. I am on the lowest dose now and after trying another time to stop, I had hot flashes. The only downside to the patch is that it is large and beige but it works!!

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